PML(NLS-) Inhibits Cell Apoptosis and Promotes Proliferation in HL-60 Cells
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منابع مشابه
PML(NLS-) Inhibits Cell Apoptosis and Promotes Proliferation in HL-60 Cells
Promyelocytic leukemia (PML) is a cell-growth suppressor, and PML-retinoic acid receptor α (PML-RARα) is known as a fusion gene of acute promyelocytic leukemia (APL). Studies have reported that neutrophil elastase(NE) cleaved bcr-1-derived PML-RARα in early myeloid cells leading to the removal of nuclear localization signal (NLS) from PML. The resultant PML without NLS named PML(NLS(-)). PML(NL...
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A unique mRNA produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (APL) patient encodes a fusion protein between the retinoic acid receptor α (RARα) and a myeloid gene product called PML. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RARα in early myeloid cells, leaving only the nuclear localization signal (NLS) of PML attached to RARα. The re...
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ژورنال
عنوان ژورنال: International Journal of Medical Sciences
سال: 2013
ISSN: 1449-1907
DOI: 10.7150/ijms.5560